{"id":201,"date":"2020-12-03T10:36:00","date_gmt":"2020-12-03T10:36:00","guid":{"rendered":"http:\/\/Maete"},"modified":"2025-05-22T15:23:40","modified_gmt":"2025-05-22T15:23:40","slug":"venous-diameter-changes-in-chronic-active-multiple-sclerosis-lesions","status":"publish","type":"post","link":"https:\/\/vgmorph.com\/de\/venous-diameter-changes-in-chronic-active-multiple-sclerosis-lesions\/","title":{"rendered":"Venous Diameter Changes in Chronic Active Multiple Sclerosis Lesions"},"content":{"rendered":"

<\/a><\/a>Claudia E. Weber<\/a>, <\/a><\/a>Matthias Kraemer<\/a>, <\/a><\/a>Andreas Dabringhaus<\/a>, <\/a><\/a>Anne Ebert<\/a>, <\/a><\/a>Michael Platten<\/a>, <\/a><\/a>Achim Gass<\/a>, <\/a><\/a>Philipp Eisele<\/a><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n
Background and Purpose<\/strong>
To investigate the temporal evolution of venous diameter in chronic active and nonenhancing shrinking multiple sclerosis (MS) lesions in a longitudinal magnetic resonance imaging (MRI) study including susceptibility\u2010weighted images (SWI).<\/h5>\n\n\n\n

Methods<\/strong>
We compared the venous diameter in chronic active and nonenhancing shrinking lesions to the venous diameter in nonenhancing stable lesions on two 3 T MRI data sets obtained 12 months apart. Chronic active and nonenhancing shrinking lesions were identified by Voxel\u2010Guided Morphometry. Coregistered, overlaid fluid\u2010attenuated inversion recovery\/SWI were analyzed for the presence of a central vein. Quantitative calculation of the venous diameter for each time point was performed on the reconstructed veins.<\/p>\n\n\n\n

Results<\/strong>
Sixty\u2010two relapsing\u2010remitting MS patients (50 women; mean age: 36 \u00b1 11 years; mean disease duration: 4 \u00b1 7 years) were included in the study. Overall, we identified 222 chronic MS lesions (48 chronic active, 48 shrinking, 126 stable) with a corresponding intralesional central vein. On baseline MRI, the mean venous diameter did not statistically differ between all subgroups, whereas on follow\u2010up MRI, the mean intralesional venous diameter was smaller in chronic active (0.92 \u00b1 0.15 mm) and shrinking lesions (0.90 \u00b1 0.19 mm) compared to stable lesions (1.10 \u00b1 0.18 mm; P<\/em> < .001).<\/p>\n\n\n\n

Conclusion<\/strong>
Our findings demonstrate venous narrowing in chronic active and nonenhancing shrinking MS lesions. The smaller diameter of intralesional veins during follow up in these lesions may reflect structural, degenerative, and metabolic changes due to chronic inflammation, (perivascular) fibrosis, collagenous thickening, and increased levels of oxygenated hemoglobin.<\/p>\n\n\n\n

First published: 03 December 2020<\/p>\n\n\n\n

Achim Gass and Philipp Eisele are joint senior authors<\/p>\n\n\n\n